In a current review, we reported the identification as well as characterization of a completely new atypical opioid receptor with one of a kind detrimental regulatory properties toward opioid peptides.1 Our benefits confirmed that ACKR3/CXCR7, hitherto referred to as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, can be a wide-spe